ZRF1 Chromatin Regulators Have Polycomb Silencing and Independent Roles in Development

Roles of Chromatin insulators in gene regulation and diseases

With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of c...

Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development.

The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that allow nuclear transcription factors and chromatin regulatory proteins to encode...

Polycomb "polypacks" the chromatin.

For decades, researchers have made a tremendous effort to characterize the chromosome organization in the nucleus. With the development of chromosome conformation capture (1) and related techniques, researchers have begun to gain insight at the molecular level into how interand intrachromosome contacts are formed. Quantitative measurement of the contact frequencies in metazoans suggested the ex...

Polycomb silencing mechanisms in Drosophila.

Update on Chromatin and Development Chromatin-Remodeling and Memory Factors. New Regulators of Plant Development

The establishment and heritable maintenance of specific epigenetic states that lead to differential gene expression are crucial for cell differentiation and development. Over the past few years, it has become apparent that epigenetic control of transcription is mediated through specific states of the chromatin structure. Therefore, changes in the chromatin structure associated with activation a...